5 Best Energy Supplements: Ranked Best to Worst

Keira's home test: PureNADH, Tru Niagen, Strong Cell, Qunol CoQ10 and RYZE lined up with handwritten labels

Let me guess how your morning goes, because it's how mine went for three years.

You sleep eight hours and wake up like you didn't. First coffee by 7, second by 9. By 2 PM you hit a wall. By dinner you're running on fumes and snapping at the people you love. So you see your doctor, get the labs, and hear that everything looks "normal," while you're sitting there still exhausted.

"Everything looks normal. You're probably just stressed."

I got tired of being tired. So last fall I turned my kitchen into a little testing lab. Over 10 weeks I tried 5 of the most popular energy supplements on the market: the ones all over Instagram, the ones at Target and GNC, and one $200-a-month "luxury" formula. I spent over $600 of my own money.

I took each one for at least 14 days, with breaks in between, and tracked one simple thing every day: did the afternoon crash show up, or not?

What I learned came down to one thing almost no brand explains, because it makes most of the shelf look like an expensive guess. Here are all 5, ranked worst to best.

Rank Supplement Cost/Day How It Works Did the Crash Stop?
★ #1 PureNADH $1.00 Direct NADH (Coenzyme 1) Yes, by day 3
#2 Strong Cell $6.67 NADH + CoQ10 + Collagen Yes, at 6.7× the price
#3 Tru Niagen $1.50 NR → NMN → NAD+ (indirect) Mild, after 2 weeks
#4 RYZE Coffee $1.20 Caffeine + mushrooms 2-3 hrs (that's the caffeine)
#5 Qunol CoQ10 $0.22 CoQ10 (heart-focused) No change at all

★ Test Winner
PureNADH box, bottle and dosing spoon during testing

I almost skipped this one. Newer brand, not on Amazon, and the pitch sounded too simple: one capsule, one ingredient. I figured the $200 formula would crush it. I was wrong.

What I liked:
  • By day 3 I felt it. By day 5, my 2 PM coffee run just stopped. No jitters, no crash, steady energy still there at 8 PM.
  • It's NADH delivered directly: the finished molecule, not a "precursor" your body has to build first. That's why it kicked in fast.
  • One capsule a day, 20 minutes before breakfast. No powders, no routine.
  • 100-day money-back guarantee, no fine print. That's not how you sell something that doesn't work.
  • Vegan, caffeine-free, no fillers, about $1.00/day on subscription.
What I didn't love:
  • Direct-to-consumer only. No Amazon, no CVS. You order from their site (mine came in 2 days).
  • Newer brand, so fewer online reviews. I trusted their lab certificates instead of a wall of star ratings.
  • Only one strength (100 mg), no lower starter dose if you like to ease in.
Check Availability at PureNADH →
Current pricing: $39.99 for a 30-day supply on subscription (save 33%), dropping to $1.00/day on the 90-day plan at $89.99 (save 40%). Prefer to buy once? The 90-capsule pack is $149.99, or $1.67/day. Either way, your first order is covered by the 100-day money-back guarantee.
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Wellura Strong Cell liquid NADH shot during testing

This was the $200 "luxury" formula. To be fair, it worked. The frustrating part is why.

What I liked:
  • Doctor-formulated stack: NADH, CoQ10, marine collagen, B-vitamins and K2. Nothing random.
  • Liquid form, claims 98% absorption, no pill to swallow.
  • Looks and feels genuinely premium.
What I didn't love:
  • $199.99/month, that's $6.67/day, about 6.7× my #1 pick.
  • You're paying for more ingredients, not more energy: the NADH does the work; the CoQ10 and collagen are along for the ride.
  • I honestly couldn't feel a difference vs. the $1/day option.
  • No guarantee anywhere close to PureNADH's 100 days.
See Strong Cell on their site →
Tru Niagen bottle on the kitchen counter during testing

The one my husband took for a year. Big science, big reputation, yet neither of us could point to a day it clearly helped.

What I liked:
  • Backed by 35+ clinical studies. Real, peer-reviewed science, not snake oil.
  • Easy to buy: GNC, Target, Amazon.
  • Around $40-50/month.
What I didn't love:
  • It's a precursor. Your body still has to convert it through several steps to reach NADH. Direct NADH skips that.
  • I felt it, but faintly, maybe 20% of the lift I got from #1.
  • Two capsules a day vs. one.
  • No money-back guarantee.
See Tru Niagen on Amazon →
RYZE Mushroom Coffee pouch during testing

I wanted to love this one. It's all over my feed and it tastes great. But "feels healthy" and "got my afternoons back" turned out to be two different things.

What I liked:
  • Actually tastes like coffee, not a chalky shake. Smooth 6-mushroom blend.
  • USDA Organic, clean sourcing.
  • Lower caffeine (~48mg) if you're trying to cut back.
  • About $36/month.
What I didn't love:
  • The kick you feel is still caffeine, and caffeine just borrows energy from later.
  • The bump lasted 2-3 hours, then I crashed, same as any coffee.
  • A nicer cup of coffee was never going to fix a deeper energy problem.
See RYZE on Amazon →
Qunol Ultra CoQ10 bottle on the kitchen counter during testing

Cheap, popular, cardiologist-recommended, so I had high hopes. It's a fine product. It's just not an energy product, no matter how it's marketed.

What I liked:
  • Dirt cheap: $26 for a 4-month supply (~$0.22/day).
  • Patented absorption formula, genuinely better than standard CoQ10.
  • The #1 cardiologist-recommended CoQ10 brand.
What I didn't love:
  • CoQ10 is really for heart support, not the afternoon-crash kind of energy.
  • Two weeks in, I felt zero change.
  • It's cheap and beloved because it's solving a different problem. "Energy" is just the word that sells it.
  • No money-back guarantee.
See Qunol on Amazon →

Why PureNADH Won, and It Wasn't Close

Here's the one thing almost no brand explains: your cells run on a molecule called NADH, also known as Coenzyme 1. It's the spark that turns food into usable energy. Most "energy" products either skip it, or hand you a precursor your body still has to convert.

That reframes the whole ranking. Tru Niagen makes you build NADH through several steps. CoQ10 is a heart supplement. Mushroom coffee is caffeine in a nicer outfit. The $200 formula buries the working ingredient under expensive extras. Only PureNADH gave my cells the finished molecule directly, which is why I felt it by day 3.

On the product side: 100 mg per capsule (most are 10 to 20 mg) and 99.9% verified purity with independent lab certification, rare in a category where most brands won't disclose purity at all.

The best test wasn't even mine. My husband switched off the Tru Niagen he'd taken for a year, and two weeks later said: "Why did I waste a year on the weaker one?"

If your energy keeps crashing every afternoon, this is the one I'd try first. With the 100-day money-back guarantee, the only thing you're really risking is staying tired.

See PureNADH Pricing & Guarantee →

Comments (3)

DR
Diana R.
A year ago · 4 Likes

Thank you for this! I've tried 3 of these (Tru Niagen, RYZE and Qunol) and I completely agree. Tru Niagen did basically nothing for me after months of taking it. RYZE is just coffee with extra steps, and Qunol never touched my energy at all. Started PureNADH about 3 weeks ago and for the first time in years I'm not crashing at 2pm. Already reordered.

RM
Robert M.
A year ago · 6 Likes

where do you actually buy PureNADH? is it on amazon or only their website?

KT
Karen T.
A year ago · 2 Likes

You can only get it direct on their site here: purenadh.com/products/purenadh. Took 2 days to arrive for me and the 100-day guarantee applies to every order.

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